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Bioscience Print

Bioscience research at the ALS can be divided into two areas: general biology (microscopy/spectroscopy) and structural biology (crystallography/diffraction). These fields provide complementary approaches to the study of living organisms from the molecular to the cellular levels. Crystallography is used to determine the atomic-resolution, three-dimensional structures of proteins and nucleic acids—the building blocks of life—as well as complexes of these molecules, the interactions of which gives rise to biological processes. Microscopy allows us to find where these biomolecules are localized in the cell and visualize the cell's overall organization. Spectroscopy also comes into play, yielding information on the chemical state of these molecules.


Bioscience Highlights

General Biology, Structural Biology

General Biology

Iron is the Key to Preserving Dinosaur Soft Tissue

Research Finds Vitamin D Deficiency Affects Bone Quality

The Molecular Ingenuity of a Unique Fish Scale

Tracking Living Cells as They Differentiate in Real Time

Bioactive Glass Scaffolds for Bone Regeneration

A New Light on Disordered Ensembles

Molecular Measurements of the Deep-Sea Oil Plume in the Gulf of Mexico

Real-Time Chemical Imaging of Bacterial Biofilm Development

Irradiation Effects on Human Cortical Bone Fracture Behavior

Lensless Imaging of Whole Biological Cells with Soft X-Rays

Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography

Harnessing the Bacterial Power of Nanomagnets

Characterization of Selective Binding of Alkali Cations with Carboxylate

Formation of Metallic Copper Nanoparticles at the Soil-Root Interface

Extracellular Proteins Promote Zinc Sulfide Aggregation

When DNA Needs to Stand Up and Be Counted

Biological Imaging by Soft X-Ray Diffraction Microscopy

Structural Biology

Molecular Switch Triggers Bacterial Pathogenicity

How Antidepressants Block Serotonin Transport

Shutting Out Ebola and Other Viruses

Exploring the Repeat-Protein Universe

A New Pathway for Radionuclide Uptake

Binding Behavior of Dopamine Transporter Key to Understanding Chemical Reactions in the Brain

A Designed Protein Maps Brain Activity

Carotenoid Pigment is the Key to Photoprotection

Ancient Proteins Help Unravel a Modern Cancer Drug’s Mechanism

Protein Instability and Lou Gehrig's Disease

Brain Receptor Structures Key to Future Therapeutics

Designer Proteins Target Epstein-Barr-Virus-Associated Cancer

Validating Computer-Designed Proteins for Vaccine

Intriguing DNA Editor Has a Structural Trigger

ALS Capabilities Reveal Multiple Functions of Ebola Virus

From Protein Structure to Function: Ring Cycle for Dilating and Constricting the Nuclear Pore

One Vaccine Leads to Another

Toward Design of a Universal Flu Vaccine

Central Activator Keeps the Circadian Clock Ticking

New Crystal Structures Lift Fog around Protein Folding

Structures of Clamp-Loader Complexes Are Key to DNA Replication

Genome Engineering with TAL Effector Nucleases

Signal Recognition Particle-Receptor Complex Structure Solved

Structure of DNA-bound FEN1 Reveals Mechanism of Action

Dynein Motor Domain Shows Ring-Shaped Motor, Buttress

Inhibiting Individual Notch Receptors Improves Treatment

A New Light on Disordered Ensembles

Giant Protease TPP II’s Structure, Mechanism Uncovered

Topoisomerase II Structure Suggests Novel DNA Cleavage Mechanism

Rotary Firing in Ring-Shaped Protein Explains Unidirectionality

Structure Illuminates Mechanism of Fungal Polyketide Cyclization

Structures of the Ribosome in Intermediate States of Ratcheting

Structures for Three Membrane Transport Proteins Yield Functional Insights

Proofreading RNA: Structure of RNA Polymerase II's Backtracked State

Protein Bridges DNA Base and Nucleotide Excision Repair Pathways

Robust, High-Throughput Analysis of Protein Structures

Protein Structure Suggests Role as Molecular Adapter

P-Glycoprotein Structure and Chemotherapy Resistance

How Dynein Binds to Microtubules

Enzyme Structure Provides Insights into Cancer and Aging

Structure of the Ebola Virus Glycoprotein Bound to an Antibody from a Human Survivor

A Key Enzyme to the Potency of an Anticancer Agent

Structure of Synaptic Connectors Solved

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

The Biological Implications of the PP2A Crystal Structure

A First Look at Yeast Fatty Acid Synthase

Unique Auxin Regulation Mechanism Discovered

Structure and Receptor Specificity of an Avian Flu Antigen

Structure of the Complete 70S Ribosome at 3.7 Å Resolution

The Initiation of Bacterial DNA Replication

High-Order Membrane Complexes from Activated G-Protein Subunits

Structure of the Kinase Domain of CaMKII and Modeling the Holoenzyme

Highest-Resolution Ribosome Structure

DNA-Binding Mechanism in Prokaryotic Partition Complex Formation

First Detailed Look at RNA Dicer

Assembly of a Molecular Needle, from the Bottom Up

Structural Basis for Activation of Cholera Toxin

Protein Flips Lipids Across Membranes

Crystal Structure of a Protein Kinase A Complex

Substrate Recognition Strategy for Botulinum Neurotoxin

How the Membrane Protein AmtB Transports Ammonia