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Therapeutic Antibody Targeting of Individual Notch Receptors Print

Notch receptors are widely expressed transmembrane proteins through which mammalian cells communicate to regulate cell fate and growth, and defects in Notch signalling are linked to many cancers. Using phage display technology, a multi-department team at Genentech has produced synthetic antibodies that act as potent and specific antagonists of Notch1 and Notch2. The cover, by Gregóire Vion of Salamander Design Studios (www.grgwr.com), depicts communication between a ligand-expressing cell (right) stimulating Notch signalling in an adjacent cell. The receptor-cell membrane expresses Notches 1 and 2 (red and blue); action of a specific antagonist means that only the blue signal is transduced to the nucleus. Article Link (PDF)