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Nickel alpha-Keto-beta-Diimine Initiators for Olefin Polymerization Print
Wednesday, 28 January 2009 00:00

In order to design and improve a catalyst, it is important to understand the structure of the present one. Whether they work in the solid state or in solution, if the catalysts can be crystallized, then their structure can be determined by single crystal x-ray diffraction on
station 11.3.1. Some chemical reactions can occur in such a way that two different handedness, i.e., mirror images of the same molecule, are produced. For applications in the pharmaceutical industry, only one of these handedness may have the desired biologically activity, the other
may have negligible or adverse affects. Separation of these mirror image molecules is very difficult and costly, therefore a catalyst which makes only the desired handedness both reduces the energy required for separation and waste at the same time. Article Link (PDF)

Structural Basis of Transcription: Role of the Trigger Loop in Substrate Specificity and Catalysis Print
Friday, 01 December 2006 00:00

Cell CoverNew structures of RNA polymerase II (pol II) transcribing complexes reveal a likely key to transcription. The trigger loop swings beneath a correct nucleoside triphosphate (NTP) in the nucleotide addition site, closing off the active center and forming an extensive network of interactions with the NTP base, sugar, phosphates, and additional pol II residues. A histidine side chain in the trigger loop, precisely positioned by these interactions, may literally "trigger" phosphodiester bond formation. Recognition and catalysis are thus coupled, ensuring the fidelity of transcription. Article Link (PDF)

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