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Ring Cycle for Dilating and Constricting the Nuclear Pore Print
Thursday, 13 June 2013 09:30

Pictured is an illustration of several nuclear pore complexes (NPCs) embedded in a cell nucleus. NPCs act as gatekeepers between a cell’s cytoplasm and its nucleus. Based on crystallographic analyses, Sozanne R. Solmaz et al. uncover the molecular mechanism that underlies the large changes in diameter of NPCs and suggest a “ring cycle” mechanism for dilating and constricting the central NPC channel. The model could explain the ability of NPCs to accommodate transport substrates of a large size range and rapidly adjust to cellular transport needs. Read the full article. (Image courtesy of Sozanne R. Solmaz, Günter Blobel, and Ivo Melčák.)