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Autophagy Ubiquitin-Like Protein Transfer In Trans Print
Friday, 04 November 2011 00:00

The cover depicts how the autophagy ubiquitin-like protein Atg8 is transferred from its E1, Atg7, to its E2, Atg3 (Taherbhoy et al., pp. 451–461). The two halves of the yin-yang represent the homodimeric Atg7. The circles within the yin-yang represent the Atg7 catalytic cysteines to which the ubiquitin-like protein Atg8 is transiently covalently linked. Each Atg7 monomer is capable of recruiting Atg3. Structural, biophysical, and biochemical data indicate that Atg3 binds to one Atg7 protomer and reaches across to accept Atg8 from the opposite protomer of Atg7 within the dimer. Article Link (PDF)

Read more about this publication in the ALS Science Brief Understanding the Autophagy Pathway.